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Tapentadol is a powerful analgesic that provides relief from moderate to severe pain. Tapentadol works by inhibiting the reuptake of norepinephrine, serotonin and dopamine in the brain. This allows tapentadol to have a strong anti-depressant effect as well. tapentadol can also be used as adjuvant therapy for patients with chronic musculoskeletal pain who are not responding adequately to treatment with non-opioid analgesics or antidepressants alone. tapentadol has been approved for use in Europe since 1997 and was approved in America only recently, under the trade name Nucynta (tapentadol).


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